3urm: Difference between revisions

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 <StructureSection load='3urm' size='340' side='right'caption='[[3urm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3urm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrfc Agrfc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3URM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3urm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3URM FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.801&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uug|3uug]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGR_C_4267, Atu2348, chvE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176299 AGRFC])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3urm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3urm OCA], [https://pdbe.org/3urm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3urm RCSB], [https://www.ebi.ac.uk/pdbsum/3urm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3urm ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CHVE_AGRFC CHVE_AGRFC]] Required for effective transcriptional induction of the vir genes by monosaccharides in response to plant signals and for normal growth and chemotaxis towards certain sugars. Function as a periplasmic multiple sugar-binding receptor protein. It does not interact with a transport system.
+[https://www.uniprot.org/uniprot/CHVE_AGRFC CHVE_AGRFC] Required for effective transcriptional induction of the vir genes by monosaccharides in response to plant signals and for normal growth and chemotaxis towards certain sugars. Function as a periplasmic multiple sugar-binding receptor protein. It does not interact with a transport system.
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Agrobacterium tumefaciens is a broad host range plant pathogen that combinatorially recognizes diverse host molecules including phenolics, low pH, and aldose monosaccharides to activate its pathogenic pathways. Chromosomal virulence gene E (chvE) encodes a periplasmic-binding protein that binds several neutral sugars and sugar acids, and subsequently interacts with the VirA/VirG regulatory system to stimulate virulence (vir) gene expression. Here, a combination of genetics, X-ray crystallography, and isothermal calorimetry reveals how ChvE binds the different monosaccharides and also shows that binding of sugar acids is pH dependent. Moreover, the potency of a sugar for vir gene expression is modulated by a transport system that also relies on ChvE. These two circuits tune the overall system to respond to sugar concentrations encountered in vivo. Finally, using chvE mutants with restricted sugar specificities, we show that there is host variation in regard to the types of sugars that are limiting for vir induction.
-Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals.,Hu X, Zhao J, Degrado WF, Binns AN Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):678-83. doi: 10.1073/pnas.1215033110., Epub 2012 Dec 24. PMID:23267119<ref>PMID:23267119</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 3urm" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Agrfc]]
+[[Category: Agrobacterium fabrum str. C58]]
 [[Category: Large Structures]]
-[[Category: Binns, A]]
+[[Category: Binns A]]
-[[Category: Degrado, W]]
+[[Category: Degrado W]]
-[[Category: Hu, X]]
+[[Category: Hu X]]
-[[Category: Zhao, J]]
+[[Category: Zhao J]]
-[[Category: Periplasmic]]
-[[Category: Periplasmic binding protein]]
-[[Category: Sugar]]
-[[Category: Sugar binding protein]]
-[[Category: Sugar-binding protein]]