3uh6: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 3: Line 3:
<StructureSection load='3uh6' size='340' side='right'caption='[[3uh6]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3uh6' size='340' side='right'caption='[[3uh6]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uh6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UH6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uh6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UH6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sdh|3sdh]], [[4sdh|4sdh]], [[3ugy|3ugy]], [[3ugz|3ugz]], [[3uh3|3uh3]], [[3uh5|3uh5]], [[3uh7|3uh7]], [[3uhb|3uhb]], [[3uhc|3uhc]], [[3uhd|3uhd]], [[3uhe|3uhe]], [[3uhg|3uhg]], [[3uhh|3uhh]], [[3uhi|3uhi]], [[3uhk|3uhk]], [[3uhn|3uhn]], [[3uhq|3uhq]], [[3uhr|3uhr]], [[3uhs|3uhs]], [[3uht|3uht]], [[3uhu|3uhu]], [[3uhv|3uhv]], [[3uhw|3uhw]], [[3uhx|3uhx]], [[3uhy|3uhy]], [[3uhz|3uhz]], [[3ui0|3ui0]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uh6 OCA], [https://pdbe.org/3uh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uh6 RCSB], [https://www.ebi.ac.uk/pdbsum/3uh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uh6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uh6 OCA], [https://pdbe.org/3uh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uh6 RCSB], [https://www.ebi.ac.uk/pdbsum/3uh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uh6 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
Here we present a meta-analysis of a large collection of static structures of a protein in the Protein Data Bank in order to extract the progression of structural events during protein function. We apply this strategy to the homodimeric hemoglobin HbI from Scapharca inaequivalvis. We derive a simple dynamic model describing how binding of the first ligand in one of the two chemically identical subunits facilitates a second binding event in the other partner subunit. The results of our ultrafast time-resolved crystallographic studies support this model. We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissors. Ligand-induced motion originating in one subunit is transmitted to the other via conserved pivot points, where the E and F' helices from two partner subunits are "bolted" together to form a stable dimer interface permitting slight relative rotation but preventing sliding.
 
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures.,Ren Z, Srajer V, Knapp JE, Royer WE Jr Proc Natl Acad Sci U S A. 2011 Dec 14. PMID:22171006<ref>PMID:22171006</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3uh6" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anain]]
[[Category: Anadara inaequivalvis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Knapp, J E]]
[[Category: Knapp JE]]
[[Category: Ren, Z]]
[[Category: Ren Z]]
[[Category: Royer, W E]]
[[Category: Royer Jr WE]]
[[Category: Srajer, V]]
[[Category: Srajer V]]
[[Category: Allostery]]
[[Category: Oxygen binding]]
[[Category: Oxygen storage]]
[[Category: Oxygen transport]]

Latest revision as of 16:58, 14 March 2024

HBI (T72A) CO boundHBI (T72A) CO bound

Structural highlights

3uh6 is a 2 chain structure with sequence from Anadara inaequivalvis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLB1_ANAIN

See Also

3uh6, resolution 2.25Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3uh6&oldid=4098865"