3tf7: Difference between revisions

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<StructureSection load='3tf7' size='340' side='right'caption='[[3tf7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='3tf7' size='340' side='right'caption='[[3tf7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tf7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TF7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tf7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TF7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2oi9|2oi9]], [[3tfk|3tfk]], [[3tjh|3tjh]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tf7 OCA], [https://pdbe.org/3tf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tf7 RCSB], [https://www.ebi.ac.uk/pdbsum/3tf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tf7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tf7 OCA], [https://pdbe.org/3tf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tf7 RCSB], [https://www.ebi.ac.uk/pdbsum/3tf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tf7 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE] Involved in the presentation of foreign antigens to the immune system.
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is essential to adaptive immunity, but it is unknown whether TCR signaling responses are influenced by the binding topology of the TCR-peptide-MHC complex. We developed yeast-displayed pMHC libraries that enabled us to identify new peptide sequences reactive with a single TCR. Structural analysis showed that four peptides bound to the TCR with distinct 3D and 2D affinities using entirely different binding chemistries. Three of the peptides that shared a common docking mode, where key TCR-MHC germline interactions are preserved, induced TCR signaling. The fourth peptide failed to induce signaling and was recognized in a substantially different TCR-MHC binding mode that apparently exceeded geometric tolerances compatible with signaling. We suggest that the stereotypical TCR-MHC docking paradigm evolved from productive signaling geometries and that TCR signaling can be modulated by peptides that are recognized in alternative TCR-pMHC binding orientations.
 
T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex.,Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC Immunity. 2011 Nov 16. PMID:22101157<ref>PMID:22101157</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3tf7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Adams, J J]]
[[Category: Adams JJ]]
[[Category: Garcia, K C]]
[[Category: Garcia KC]]
[[Category: Kranz, D M]]
[[Category: Kranz DM]]
[[Category: Antigen recognition]]
[[Category: Ig and mhc]]
[[Category: Immune system]]
[[Category: Membrane receptor]]
[[Category: Tcr-pmhc]]

Revision as of 16:26, 14 March 2024

42F3 QL9/H2-Ld complex42F3 QL9/H2-Ld complex

Structural highlights

3tf7 is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HA1L_MOUSE Involved in the presentation of foreign antigens to the immune system.

3tf7, resolution 2.75Å

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