3sm9: Difference between revisions

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<StructureSection load='3sm9' size='340' side='right'caption='[[3sm9]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='3sm9' size='340' side='right'caption='[[3sm9]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SM9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SM9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPRC1C, GRM3, MGLUR3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm9 OCA], [https://pdbe.org/3sm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3sm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sm9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm9 OCA], [https://pdbe.org/3sm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3sm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sm9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>
[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Cossar, D]]
[[Category: Cossar D]]
[[Category: Crombet, L]]
[[Category: Crombet L]]
[[Category: Dobrovetsky, E]]
[[Category: Dobrovetsky E]]
[[Category: Dong, A]]
[[Category: Dong A]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Khutoreskaya, G]]
[[Category: Khutoreskaya G]]
[[Category: Structural genomic]]
[[Category: Seitova A]]
[[Category: Seitova, A]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Wernimont AK]]
[[Category: Wernimont, A K]]
[[Category: Cell membrane]]
[[Category: G-protein coupled receptor]]
[[Category: Glycoprotein]]
[[Category: Membrane]]
[[Category: Olfaction]]
[[Category: Phosphoprotein]]
[[Category: Receptor]]
[[Category: Sensory transduction]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Transducer]]
[[Category: Transmembrane]]
[[Category: Transmembrane helix]]

Latest revision as of 16:01, 14 March 2024

Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonistCrystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist

Structural highlights

3sm9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.26Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GRM3_HUMAN G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.[1]

See Also

References

  1. ↑ Makoff A, Volpe F, Lelchuk R, Harrington K, Emson P. Molecular characterization and localization of human metabotropic glutamate receptor type 3. Brain Res Mol Brain Res. 1996 Aug;40(1):55-63. PMID:8840013

3sm9, resolution 2.26Å

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