3q1s: Difference between revisions

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<StructureSection load='3q1s' size='340' side='right'caption='[[3q1s]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='3q1s' size='340' side='right'caption='[[3q1s]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q1s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1S FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q1s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1S FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fn0|3fn0]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL22, ILTIF, ZCYTO18, UNQ3099/PRO10096 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1s OCA], [https://pdbe.org/3q1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1s RCSB], [https://www.ebi.ac.uk/pdbsum/3q1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1s OCA], [https://pdbe.org/3q1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1s RCSB], [https://www.ebi.ac.uk/pdbsum/3q1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN]] Cytokine that contributes to the inflammatory response in vivo.  
[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Antibody Z13e1 is a relatively broadly neutralizing anti-human immunodeficiency virus type 1 antibody that recognizes the membrane-proximal external region (MPER) of the human immunodeficiency virus type 1 envelope glycoprotein gp41. Based on the crystal structure of an MPER epitope peptide in complex with Z13e1 Fab, we identified an unrelated protein, interleukin (IL)-22, with a surface-exposed region that is structurally homologous in its backbone to the gp41 Z13e1 epitope. By grafting the gp41 Z13e1 epitope sequence onto the structurally homologous region in IL-22, we engineered a novel protein (Z13-IL22-2) that contains the MPER epitope sequence for use as a potential immunogen and as a reagent for the detection of Z13e1-like antibodies. The Z13-IL22-2 protein binds Fab Z13e1 with a K(d) of 73 nM. The crystal structure of Z13-IL22-2 in complex with Fab Z13e1 shows that the epitope region is faithfully replicated in the Fab-bound scaffold protein; however, isothermal calorimetry studies indicate that Fab binding to Z13-IL22-2 is not a lock-and-key event, leaving open the question of whether conformational changes upon binding occur in the Fab, in Z13-IL-22, or in both.
 
Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope.,Stanfield RL, Julien JP, Pejchal R, Gach JS, Zwick MB, Wilson IA J Mol Biol. 2011 Dec 2;414(3):460-76. Epub 2011 Oct 15. PMID:22033480<ref>PMID:22033480</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3q1s" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gach, J S]]
[[Category: Gach JS]]
[[Category: Julien, J P]]
[[Category: Julien J-P]]
[[Category: Pejchal, R]]
[[Category: Pejchal R]]
[[Category: Stanfield, R L]]
[[Category: Stanfield RL]]
[[Category: Wilson, I A]]
[[Category: Wilson IA]]
[[Category: Zwick, M B]]
[[Category: Zwick MB]]
[[Category: Antibody]]
[[Category: Gp41]]
[[Category: Immune system-cytokine complex]]
[[Category: Immunoglobulin fold]]

Revision as of 14:30, 14 March 2024

HIV-1 neutralizing antibody Z13e1 in complex with epitope display proteinHIV-1 neutralizing antibody Z13e1 in complex with epitope display protein

Structural highlights

3q1s is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.15Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL22_HUMAN Cytokine that contributes to the inflammatory response in vivo.

See Also

3q1s, resolution 2.15Å

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OCA
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