1r09: Difference between revisions

Revision as of 06:54, 3 May 2008

HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837

OverviewOverview

The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible.

About this StructureAbout this Structure

1R09 is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.

ReferenceReference

Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:1847215 Page seeded by OCA on Sat May 3 06:54:53 2008

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OCA

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 [[Image:1r09.jpg|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_1r09", creates the "Structure Box" on the page.
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-}}
 '''HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837'''
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 [[Category: Minor, I.]]
 [[Category: Rossmann, M G.]]
-[[Category: icosahedral virus]]
+[[Category: Icosahedral virus]]
-[[Category: rhinovirus coat protein]]
+[[Category: Rhinovirus coat protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:54:53 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:22 2008''