1r02: Difference between revisions
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'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness''' | '''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness''' | ||
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==About this Structure== | ==About this Structure== | ||
1R02 is a [[Single protein]] structure | 1R02 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Kim, J I.]] | [[Category: Kim, J I.]] | ||
[[Category: Lee, W.]] | [[Category: Lee, W.]] | ||
[[Category: | [[Category: Helix-loop-helix]] | ||
[[Category: | [[Category: Turn]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:39 2008'' | |||
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Revision as of 06:54, 3 May 2008
Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness
OverviewOverview
Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
About this StructureAbout this Structure
1R02 is a Single protein structure. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620 Page seeded by OCA on Sat May 3 06:54:39 2008