Proteopedia

1b6e: Difference between revisions

← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
<StructureSection load='1b6e' size='340' side='right'caption='[[1b6e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='1b6e' size='340' side='right'caption='[[1b6e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1b6e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B6E FirstGlance]. <br>
<table><tr><td colspan='2'>[[1b6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B6E FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b6e OCA], [https://pdbe.org/1b6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b6e RCSB], [https://www.ebi.ac.uk/pdbsum/1b6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b6e ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b6e OCA], [https://pdbe.org/1b6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b6e RCSB], [https://www.ebi.ac.uk/pdbsum/1b6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b6e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KLRD1_HUMAN KLRD1_HUMAN]] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.  
[https://www.uniprot.org/uniprot/KLRD1_HUMAN KLRD1_HUMAN] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 18: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b6e ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b6e ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the extracellular domain of CD94, a component of the CD94/NKG2 NK cell receptor, has been determined to 2.6 A resolution, revealing a unique variation of the C-type lectin fold. In this variation, the second alpha helix, corresponding to residues 102-112, is replaced by a loop, the putative carbohydrate-binding site is significantly altered, and the Ca2+-binding site appears nonfunctional. This structure may serve as a prototype for other NK cell receptors such as Ly-49, NKR-P1, and CD69. The CD94 dimer observed in the crystal has an extensive hydrophobic interface that stabilizes the loop conformation of residues 102-112. The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how NKG2 interacts with CD94.
Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors.,Boyington JC, Riaz AN, Patamawenu A, Coligan JE, Brooks AG, Sun PD Immunity. 1999 Jan;10(1):75-82. PMID:10023772<ref>PMID:10023772</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1b6e" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Boyington, J C]]
[[Category: Boyington JC]]
[[Category: Brooks, A G]]
[[Category: Brooks AG]]
[[Category: Coligan, J E]]
[[Category: Coligan JE]]
[[Category: Patamawenu, A]]
[[Category: Patamawenu A]]
[[Category: Riaz, A N]]
[[Category: Riaz AN]]
[[Category: Sun, P D]]
[[Category: Sun PD]]
[[Category: C-type lectin]]
[[Category: C-type lectin-like]]
[[Category: Nk cell]]
[[Category: Nkd]]
[[Category: Receptor]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/w/1b6e"