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==DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE==
==DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE==
<StructureSection load='1ak6' size='340' side='right'caption='[[1ak6]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1ak6' size='340' side='right'caption='[[1ak6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ak6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AK6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ak6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AK6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ak7|1ak7]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ak6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ak6 OCA], [https://pdbe.org/1ak6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ak6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ak6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ak6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ak6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ak6 OCA], [https://pdbe.org/1ak6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ak6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ak6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ak6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DEST_PIG DEST_PIG]] Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.  
[https://www.uniprot.org/uniprot/DEST_PIG DEST_PIG] Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ak6 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ak6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Destrin is an isoprotein of cofilin that regulates actin cytoskeleton in various eukaryotes. We determined the tertiary structure of destrin by triple-resonance multidimensional nuclear magnetic resonance. In spite of there being no significant amino acid sequence homology, we found that the folding of destrin was strikingly similar to that of repeated segments in the gelsolin family, which resulted in a new protein fold group. Sequential dissimilarity of the actin-binding helix of destrin to that of gelsolin explains the Ca2+-independent actin-binding of destrin. Possible mechanisms of phosphorylation-sensitive phosphoinositide-competitive actin binding, of pH-dependent filament severing, and of nuclear translocation with actin in response to stresses, are discussed on the basis of the tertiary structure.
Tertiary structure of destrin and structural similarity between two actin-regulating protein families.,Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F Cell. 1996 Jun 28;85(7):1047-55. PMID:8674111<ref>PMID:8674111</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ak6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hatanaka, H]]
[[Category: Sus scrofa]]
[[Category: Ichikawa, S]]
[[Category: Hatanaka H]]
[[Category: Inagaki, F]]
[[Category: Ichikawa S]]
[[Category: Moriyama, K]]
[[Category: Inagaki F]]
[[Category: Ogura, K]]
[[Category: Moriyama K]]
[[Category: Yahara, I]]
[[Category: Ogura K]]
[[Category: Actin depolymerization factor]]
[[Category: Yahara I]]
[[Category: Actin-binding protein]]

Revision as of 18:25, 13 March 2024

DESTRIN, NMR, MINIMIZED AVERAGE STRUCTUREDESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE

Structural highlights

1ak6 is a 1 chain structure with sequence from Homo sapiens and Sus scrofa. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DEST_PIG Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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