1agq: Difference between revisions

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<StructureSection load='1agq' size='340' side='right'caption='[[1agq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1agq' size='340' side='right'caption='[[1agq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1agq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1agq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGQ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agq OCA], [https://pdbe.org/1agq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agq RCSB], [https://www.ebi.ac.uk/pdbsum/1agq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agq ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agq OCA], [https://pdbe.org/1agq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agq RCSB], [https://www.ebi.ac.uk/pdbsum/1agq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GDNF_RAT GDNF_RAT]] Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.<ref>PMID:10828539</ref>
[https://www.uniprot.org/uniprot/GDNF_RAT GDNF_RAT] Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.<ref>PMID:10828539</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agq ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agq ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.,Eigenbrot C, Gerber N Nat Struct Biol. 1997 Jun;4(6):435-8. PMID:9187648<ref>PMID:9187648</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1agq" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Eigenbrot, C]]
[[Category: Rattus norvegicus]]
[[Category: Gerber, N]]
[[Category: Eigenbrot C]]
[[Category: Cystine knot]]
[[Category: Gerber N]]
[[Category: Growth factor]]
[[Category: Neurotrophic factor]]

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