6ebv: Difference between revisions

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<StructureSection load='6ebv' size='340' side='right'caption='[[6ebv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='6ebv' size='340' side='right'caption='[[6ebv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ebv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EBV FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ebv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EBV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=27Q:N-HEPTYL-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE'>27Q</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=27Q:N-HEPTYL-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE'>27Q</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ebv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ebv OCA], [http://pdbe.org/6ebv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ebv RCSB], [http://www.ebi.ac.uk/pdbsum/6ebv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ebv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ebv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ebv OCA], [https://pdbe.org/6ebv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ebv RCSB], [https://www.ebi.ac.uk/pdbsum/6ebv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ebv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A0D6HHM8_STAAU A0A0D6HHM8_STAAU]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.[HAMAP-Rule:MF_01273]  
[https://www.uniprot.org/uniprot/COAW_STAA8 COAW_STAA8] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:12760898</ref>
 
==See Also==
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pantothenate kinase]]
[[Category: Antoshchenko, T]]
[[Category: Barnard, L]]
[[Category: Chen, Y]]
[[Category: Huang, Y H]]
[[Category: Park, H]]
[[Category: Strauss, E]]
[[Category: Adp]]
[[Category: Pantothenate analog]]
[[Category: Sapank]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Transferase]]
[[Category: Antoshchenko T]]
[[Category: Barnard L]]
[[Category: Chen Y]]
[[Category: Huang YH]]
[[Category: Park H]]
[[Category: Strauss E]]

Latest revision as of 17:40, 13 March 2024

Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-N7-PanStaphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-N7-Pan

Structural highlights

6ebv is a 4 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

COAW_STAA8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.[1]

See Also

References

  1. ↑ Choudhry AE, Mandichak TL, Broskey JP, Egolf RW, Kinsland C, Begley TP, Seefeld MA, Ku TW, Brown JR, Zalacain M, Ratnam K. Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections. Antimicrob Agents Chemother. 2003 Jun;47(6):2051-5. PMID:12760898 doi:10.1128/AAC.47.6.2051-2055.2003

6ebv, resolution 3.00Å

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