6e0t: Difference between revisions

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==C-terminal domain of Fission Yeast OFD1==
==C-terminal domain of Fission Yeast OFD1==
<StructureSection load='6e0t' size='340' side='right'caption='[[6e0t]]' scene=''>
<StructureSection load='6e0t' size='340' side='right'caption='[[6e0t]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6E0T FirstGlance]. <br>
<table><tr><td colspan='2'>[[6e0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0T FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6e0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0t OCA], [http://pdbe.org/6e0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0t RCSB], [http://www.ebi.ac.uk/pdbsum/6e0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0t ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0t OCA], [https://pdbe.org/6e0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0t RCSB], [https://www.ebi.ac.uk/pdbsum/6e0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OFD1_SCHPO OFD1_SCHPO] Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression.<ref>PMID:19158663</ref> <ref>PMID:24550462</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Amzel LM]]
[[Category: Amzel LM]]
[[Category: Bianchet MA]]
[[Category: Bianchet MA]]
[[Category: Espenshade PJ]]
[[Category: Espenshade PJ]]
[[Category: Yeh T]]
[[Category: Yeh T]]

Latest revision as of 17:38, 13 March 2024

C-terminal domain of Fission Yeast OFD1C-terminal domain of Fission Yeast OFD1

Structural highlights

6e0t is a 1 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.02Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OFD1_SCHPO Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression.[1] [2]

References

  1. ↑ Lee CY, Stewart EV, Hughes BT, Espenshade PJ. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J. 2009 Jan 21;28(2):135-43. doi: 10.1038/emboj.2008.271. PMID:19158663 doi:http://dx.doi.org/10.1038/emboj.2008.271
  2. ↑ Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4019-24. doi:, 10.1073/pnas.1311750111. Epub 2014 Feb 18. PMID:24550462 doi:http://dx.doi.org/10.1073/pnas.1311750111

6e0t, resolution 2.02Å

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