6d1s: Difference between revisions

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 <StructureSection load='6d1s' size='340' side='right'caption='[[6d1s]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6d1s]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1S FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6d1s]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii_3937 Dickeya dadantii 3937] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D1S FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1s OCA], [http://pdbe.org/6d1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1s RCSB], [http://www.ebi.ac.uk/pdbsum/6d1s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1s ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1s OCA], [https://pdbe.org/6d1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d1s RCSB], [https://www.ebi.ac.uk/pdbsum/6d1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1s ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Disease ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Juvenile myoclonic epilepsy;Childhood absence epilepsy;Dravet syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
-Type A gamma-aminobutyric acid receptors (GABAARs) are inhibitory pentameric ligand-gated ion channels in the brain. Many anesthetics and neurosteroids act through binding to the GABAAR transmembrane domain (TMD), but the structural basis of their actions is not well understood and no resting-state GABAAR structure has been determined. Here, we report crystal structures of apo and the neurosteroid anesthetic alphaxalone-bound desensitized chimeric alpha1GABAAR (ELIC-alpha1GABAAR). The chimera retains the functional and pharmacological properties of GABAARs, including potentiation, activation and desensitization by alphaxalone. The apo-state structure reveals an unconventional activation gate at the intracellular end of the pore. The desensitized structure illustrates molecular determinants for alphaxalone binding to an inter-subunit TMD site. These structures suggest a plausible signaling pathway from alphaxalone binding at the bottom of the TMD to the channel gate in the pore-lining TM2 through the TM1-TM2 linker. The study provides a framework to discover new GABAAR modulators with therapeutic potential.
+== Function ==
+[https://www.uniprot.org/uniprot/E0SJQ4_DICD3 E0SJQ4_DICD3] [https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
-Structural basis of neurosteroid anesthetic action on GABAA receptors.,Chen Q, Wells MM, Arjunan P, Tillman TS, Cohen AE, Xu Y, Tang P Nat Commun. 2018 Sep 28;9(1):3972. doi: 10.1038/s41467-018-06361-4. PMID:30266951<ref>PMID:30266951</ref>
+==See Also==
+*[[GABA receptor 3D structures|GABA receptor 3D structures]]
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 6d1s" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Dickeya dadantii 3937]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arjunan, P]]
+[[Category: Arjunan P]]
-[[Category: Chen, Q]]
+[[Category: Chen Q]]
-[[Category: Cohen, A E]]
+[[Category: Cohen AE]]
-[[Category: Tang, P]]
+[[Category: Tang P]]
-[[Category: Xu, Y]]
+[[Category: Xu Y]]
-[[Category: Alphaxalone]]
-[[Category: Anesthetic]]
-[[Category: Gabaa receptor]]
-[[Category: Neurosteroid]]
-[[Category: Protein transport]]