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| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/Q8I6L9_TRYCR Q8I6L9_TRYCR] | | [https://www.uniprot.org/uniprot/Q8I6L9_TRYCR Q8I6L9_TRYCR] |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE.
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| Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi.,Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922<ref>PMID:21840922</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 3atz" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[NADPH dehydrogenase|NADPH dehydrogenase]] | | *[[NADPH dehydrogenase|NADPH dehydrogenase]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |