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2e0z: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2e0z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E0Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[2e0z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E0Z FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e0z OCA], [https://pdbe.org/2e0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e0z RCSB], [https://www.ebi.ac.uk/pdbsum/2e0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e0z ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e0z OCA], [https://pdbe.org/2e0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e0z RCSB], [https://www.ebi.ac.uk/pdbsum/2e0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e0z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENCP1_PYRFU ENCP1_PYRFU] Fusion of the shell and cargo protein of a type 1 encapsulin nanocompartment (PubMed:17397865). The nanocompartment is probably involved in iron storage (Probable). Expression in E.coli generates spherical particles (PfSPs) about 30 nm in diameter (PubMed:16091594).<ref>PMID:16091594</ref> <ref>PMID:17397865</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e0z ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e0z ConSurf].
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== Publication Abstract from PubMed ==
Pyrococcus furiosus is a hyperthermophilic archaeal microorganism found near deep-sea thermal vents and its optimal growth temperature of 100 degrees C. Recently, a 38.8-kDa protein from P. furiosus DSM 3638 was isolated and characterized. Electron microscopy revealed that this protein aggregated as spheres of approximately 30 nm in diameter, which we designated P. furiosus virus-like particles (PfVs). X-ray crystallographic analysis at 3.6-A resolution revealed that each PfV consisted of 180 copies of the 38.8-kDa protein and retained T=3 icosahedral symmetry, as is often the case in spherical viruses. The total molecular mass of each particle was approximately 7 MDa. An examination of capsid structures suggested strong evolutionary links among PfV, tailed double-stranded DNA bacteriophages, and herpes viruses. The similar three-dimensional structures of the various coat proteins indicate that these viral capsids might have originated and evolved from a common ancestor. The structure of PfV provides a previously undescribed example of viral relationships across the three domains of life (Eukarya, Bacteria, and Archaea).


The crystal structure of a virus-like particle from the hyperthermophilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses.,Akita F, Chong KT, Tanaka H, Yamashita E, Miyazaki N, Nakaishi Y, Suzuki M, Namba K, Ono Y, Tsukihara T, Nakagawa A J Mol Biol. 2007 May 18;368(5):1469-83. Epub 2007 Mar 2. PMID:17397865<ref>PMID:17397865</ref>
==See Also==
 
*[[Art:Faberge Eggs|Art:Faberge Eggs]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2e0z" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Akita, F]]
[[Category: Akita F]]
[[Category: Chong, K T]]
[[Category: Chong KT]]
[[Category: Miyazaki, N]]
[[Category: Miyazaki N]]
[[Category: Nakagawa, A]]
[[Category: Nakagawa A]]
[[Category: Nakaishi, Y]]
[[Category: Nakaishi Y]]
[[Category: Namba, K]]
[[Category: Namba K]]
[[Category: Ono, Y]]
[[Category: Ono Y]]
[[Category: Suzuki, M]]
[[Category: Suzuki M]]
[[Category: Tanaka, H]]
[[Category: Tanaka H]]
[[Category: Tsukihara, T]]
[[Category: Tsukihara T]]
[[Category: Yamashita, E]]
[[Category: Yamashita E]]
[[Category: Bacteriophage]]
[[Category: Hk97]]
[[Category: T4]]
[[Category: Virus]]
[[Category: Virus like particle]]
[[Category: Virus-like particle]]

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