1xi4: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xi4]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The April 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Clathrin''  by Graham T. Johnson and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 10.2210/rcsb_pdb/mom_2007_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XI4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xi4]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The April 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Clathrin''  by Graham T. Johnson and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 10.2210/rcsb_pdb/mom_2007_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XI4 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xi5|1xi5]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xi4 OCA], [https://pdbe.org/1xi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xi4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xi4 OCA], [https://pdbe.org/1xi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xi4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. [[https://www.uniprot.org/uniprot/CLCA_BOVIN CLCA_BOVIN]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.  
[https://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xi4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xi4 ConSurf].
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<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Clathrin-coated vesicles are important vehicles of membrane traffic in cells. We report the structure of a clathrin lattice at subnanometre resolution, obtained from electron cryomicroscopy of coats assembled in vitro. We trace most of the 1,675-residue clathrin heavy chain by fitting known crystal structures of two segments, and homology models of the rest, into the electron microscopy density map. We also define the position of the central helical segment of the light chain. A helical tripod, the carboxy-terminal parts of three heavy chains, projects inward from the vertex of each three-legged clathrin triskelion, linking that vertex to 'ankles' of triskelions centred two vertices away. Analysis of coats with distinct diameters shows an invariant pattern of contacts in the neighbourhood of each vertex, with more variable interactions along the extended parts of the triskelion 'legs'. These invariant local interactions appear to stabilize the lattice, allowing assembly and uncoating to be controlled by events at a few specific sites.
Molecular model for a complete clathrin lattice from electron cryomicroscopy.,Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T Nature. 2004 Dec 2;432(7017):573-9. Epub 2004 Oct 24. PMID:15502812<ref>PMID:15502812</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1xi4" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Clathrin 3D structures|Clathrin 3D structures]]
*[[Clathrin 3D structures|Clathrin 3D structures]]
== References ==
<references/>
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</SX>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Cheng, Y]]
[[Category: Cheng Y]]
[[Category: Fotin, A]]
[[Category: Fotin A]]
[[Category: Grigorieff, N]]
[[Category: Grigorieff N]]
[[Category: Harrison, S C]]
[[Category: Harrison SC]]
[[Category: Kirchhausen, T]]
[[Category: Kirchhausen T]]
[[Category: Sliz, P]]
[[Category: Sliz P]]
[[Category: Walz, T]]
[[Category: Walz T]]
[[Category: Alpha-zig-zag]]
[[Category: Beta-propeller]]
[[Category: Endocytosis-exocytosis complex]]

Latest revision as of 16:36, 13 March 2024

Clathrin D6 CoatClathrin D6 Coat

1xi4, resolution 7.90Å

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