1qw6: Difference between revisions

Revision as of 06:46, 3 May 2008

Rat neuronal nitric oxide synthase oxygenase domain in complex with N-omega-propyl-L-Arg.

OverviewOverview

The high level of amino acid conservation and structural similarity in the immediate vicinity of the substrate binding sites of the oxygenase domains of the nitric-oxide synthase (NOS) isoforms (eNOSoxy, iNOSoxy, and nNOSoxy) make the interpretation of the structural basis of inhibitor isoform specificity a challenge and provide few clues for the design of new selective compounds. Crystal structures of iNOSoxy and nNOSoxy complexed with the inhibitors W1400 and Nomega-propyl-l-arginine provide a rationale for their isoform specificity. It involves differences outside the immediate active site as well as a conformational flexibility in the active site that allows the adoption of distinct conformations in response to interactions with the inhibitors. This flexibility is determined by isoform-specific residues outside the active site.

About this StructureAbout this Structure

1QW6 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms., Fedorov R, Hartmann E, Ghosh DK, Schlichting I, J Biol Chem. 2003 Nov 14;278(46):45818-25. Epub 2003 Sep 3. PMID:12954642 Page seeded by OCA on Sat May 3 06:46:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1qw6.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1qw6 |SIZE=350|CAPTION= <scene name='initialview01'>1qw6</scene>, resolution 2.1&Aring;
+The line below this paragraph, containing "STRUCTURE_1qw6", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=3AR:N-OMEGA-PROPYL-L-ARGININE'>3AR</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= NOS1 OR BNOS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+-->
-|DOMAIN=
+{{STRUCTURE_1qw6|  PDB=1qw6  |  SCENE=  }}
-|RELATEDENTRY=[[1qw4|1QW4]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qw6 OCA], [http://www.ebi.ac.uk/pdbsum/1qw6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qw6 RCSB]</span>
-}}
 '''Rat neuronal nitric oxide synthase oxygenase domain in complex with N-omega-propyl-L-Arg.'''
@@ Line 30: / Line 27: @@
 [[Category: Hartmann, E.]]
 [[Category: Schlichting, I.]]
-[[Category: rat nnosoxy complex with n-omega-propyl-l-arg]]
+[[Category: Rat nnosoxy complex with n-omega-propyl-l-arg]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:46:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:19:49 2008''