7luv: Difference between revisions
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==== | ==Cryo-EM structure of the yeast THO-Sub2 complex== | ||
<StructureSection load='7luv' size='340' side='right'caption='[[7luv]]' scene=''> | <StructureSection load='7luv' size='340' side='right'caption='[[7luv]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7luv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_bayanus Saccharomyces bayanus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LUV FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7luv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7luv OCA], [https://pdbe.org/7luv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7luv RCSB], [https://www.ebi.ac.uk/pdbsum/7luv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7luv ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7luv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7luv OCA], [https://pdbe.org/7luv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7luv RCSB], [https://www.ebi.ac.uk/pdbsum/7luv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7luv ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HPR1_YEAST HPR1_YEAST] Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.<ref>PMID:12093753</ref> <ref>PMID:12871933</ref> <ref>PMID:14527416</ref> <ref>PMID:15192704</ref> | |||
==See Also== | |||
*[[Helicase 3D structures|Helicase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Saccharomyces bayanus]] | ||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Ren Y]] | |||
[[Category: Xie Y]] | |||