7lr0: Difference between revisions

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<StructureSection load='7lr0' size='340' side='right'caption='[[7lr0]], [[Resolution|resolution]] 3.81&Aring;' scene=''>
<StructureSection load='7lr0' size='340' side='right'caption='[[7lr0]], [[Resolution|resolution]] 3.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7lr0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LR0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7lr0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ictidomys_tridecemlineatus Ictidomys tridecemlineatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LR0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DY:(6E)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE'>4DY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.81&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7lqy|7lqy]], [[7lqz|7lqz]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DY:(6E)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE'>4DY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lr0 OCA], [https://pdbe.org/7lr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lr0 RCSB], [https://www.ebi.ac.uk/pdbsum/7lr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lr0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lr0 OCA], [https://pdbe.org/7lr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lr0 RCSB], [https://www.ebi.ac.uk/pdbsum/7lr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lr0 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/I3LZN5_ICTTR I3LZN5_ICTTR]
Transient receptor potential (TRP) channels are polymodal molecular sensors involved in numerous physiological processes and implicated in a variety of human diseases. Several structures of the founding member of the TRP channel family, TRPV1, are available, all of which were determined for the protein missing the N- and C-termini and the extracellular S5-P-loop. Here, we present structures of the full-length thirteen-lined ground squirrel TRPV1 solved by cryo-EM. Our structures resolve the extracellular cap domain formed by the S5-P-loops and the C-terminus that wraps around the three-stranded beta-sheet connecting elements of the TRPV1 intracellular skirt. The cap domain forms a dome above the pore's extracellular entrance, with four portals leading to the ion conductance pathway. Deletion of the cap increases the TRPV1 average conductance, reduces the open probability and affects ion selectivity. Our data show that both the termini and the cap domain are critical determinants of TRPV1 function.


Extracellular cap domain is an essential component of the TRPV1 gating mechanism.,Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI Nat Commun. 2021 Apr 12;12(1):2154. doi: 10.1038/s41467-021-22507-3. PMID:33846324<ref>PMID:33846324</ref>
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7lr0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ictidomys tridecemlineatus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Nadezhdin, K D]]
[[Category: Nadezhdin KD]]
[[Category: Neuberger, A]]
[[Category: Neuberger A]]
[[Category: Sobolevsky, A I]]
[[Category: Sobolevsky AI]]
[[Category: Capsaicin]]
[[Category: Membrane protein]]
[[Category: Transient receptor potential v family member 1]]
[[Category: Trp channel]]
[[Category: Trpv1 full length]]
[[Category: Trpv1 wild type]]

Latest revision as of 18:00, 6 March 2024

Structure of squirrel TRPV1 in complex with capsaicinStructure of squirrel TRPV1 in complex with capsaicin

Structural highlights

7lr0 is a 4 chain structure with sequence from Ictidomys tridecemlineatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.81Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

I3LZN5_ICTTR

See Also

7lr0, resolution 3.81Å

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