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==Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state== | ==Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state== | ||
<StructureSection load='7lhe' size='340' side='right'caption='[[7lhe]]' scene=''> | <StructureSection load='7lhe' size='340' side='right'caption='[[7lhe]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LHE FirstGlance]. <br> | <table><tr><td colspan='2'>[[7lhe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LHE FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lhe OCA], [https://pdbe.org/7lhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lhe RCSB], [https://www.ebi.ac.uk/pdbsum/7lhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lhe ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLX:(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL'>PLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lhe OCA], [https://pdbe.org/7lhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lhe RCSB], [https://www.ebi.ac.uk/pdbsum/7lhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lhe ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | |||
==See Also== | |||
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Baker ML]] | [[Category: Baker ML]] | ||
[[Category: Baker MR]] | [[Category: Baker MR]] | ||
[[Category: Fan G]] | [[Category: Fan G]] | ||
[[Category: Serysheva II]] | [[Category: Serysheva II]] | ||
Latest revision as of 17:59, 6 March 2024
Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-stateStructure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state
Structural highlights
FunctionITPR1_RAT Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). See Also |
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