1qqw: Difference between revisions

Revision as of 06:36, 3 May 2008

CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE

OverviewOverview

Catalase (E.C. 1.11.1.6) was purified from human erythrocytes and crystallized in three different forms: orthorhombic, hexagonal and tetragonal. The structure of the orthorhombic crystal form of human erythrocyte catalase (HEC), with space group P2(1)2(1)2(1) and unit-cell parameters a = 84.9, b = 141.7, c = 232.5 A, was determined and refined with 2.75 A resolution data. Non-crystallographic symmetry restraints were employed and the resulting R value and R(free) were 0.206 and 0.272, respectively. The overall structure and arrangement of HEC molecules in the orthorhombic unit cell were very similar to those of bovine liver catalase (BLC). However, no NADPH was observed in the HEC crystal and a water was bound to the active-site residue His75. Conserved lattice interactions suggested a common growth mechanism for the orthorhombic crystals of HEC and BLC.

About this StructureAbout this Structure

1QQW is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1QQW with [Catalase]. Full crystallographic information is available from OCA.

ReferenceReference

Structure of human erythrocyte catalase., Ko TP, Safo MK, Musayev FN, Di Salvo ML, Wang C, Wu SH, Abraham DJ, Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):241-5. PMID:10666617 Page seeded by OCA on Sat May 3 06:36:12 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1qqw.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1qqw |SIZE=350|CAPTION= <scene name='initialview01'>1qqw</scene>, resolution 2.75&Aring;
+The line below this paragraph, containing "STRUCTURE_1qqw", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1qqw|  PDB=1qqw  |  SCENE=  }}
-|RELATEDENTRY=[[4blc|4BLC]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqw OCA], [http://www.ebi.ac.uk/pdbsum/1qqw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qqw RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE'''
@@ Line 32: / Line 29: @@
 [[Category: Wang, C.]]
 [[Category: Wu, S H.]]
-[[Category: heme protein]]
+[[Category: Heme protein]]
-[[Category: lattice contact]]
+[[Category: Lattice contact]]
-[[Category: no nadp]]
+[[Category: No nadp]]
-[[Category: water]]
+[[Category: Water]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:36:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:17:44 2008''