8vy8: Difference between revisions

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'''Unreleased structure'''


The entry 8vy8 is ON HOLD
==Recombinant alpha bungarotoxin complexed with HAP peptide==
 
<StructureSection load='8vy8' size='340' side='right'caption='[[8vy8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Xu, J., Lei, X., Chen, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8vy8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VY8 FirstGlance]. <br>
Description: Recombinant alpha bungarotoxin complexed with HAP peptide
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
[[Category: Xu, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vy8 OCA], [https://pdbe.org/8vy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vy8 RCSB], [https://www.ebi.ac.uk/pdbsum/8vy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vy8 ProSAT]</span></td></tr>
[[Category: Lei, X]]
</table>
[[Category: Chen, L]]
== Function ==
[https://www.uniprot.org/uniprot/3L21V_BUNMU 3L21V_BUNMU] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615]<ref>PMID:10497260</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bungarus multicinctus]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Chen L]]
[[Category: Lei X]]
[[Category: Xu J]]

Revision as of 15:11, 6 March 2024

Recombinant alpha bungarotoxin complexed with HAP peptideRecombinant alpha bungarotoxin complexed with HAP peptide

Structural highlights

8vy8 is a 8 chain structure with sequence from Bungarus multicinctus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

3L21V_BUNMU Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615][1]

References

  1. ↑ Chang L, Lin S, Huang H, Hsiao M. Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha-bungarotoxin isotoxins is not derived from edited mRNAs. Nucleic Acids Res. 1999 Oct 15;27(20):3970-5. PMID:10497260

8vy8, resolution 2.40Å

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OCA
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