4v4b: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[4v4b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [https://pdbe.org/4v4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [https://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.7&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [https://pdbe.org/4v4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [https://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>
 </table>
 == Function ==
 [https://www.uniprot.org/uniprot/EF2_YEAST EF2_YEAST]
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-An 11.7-A-resolution cryo-EM map of the yeast 80S.eEF2 complex in the presence of the antibiotic sordarin was interpreted in molecular terms, revealing large conformational changes within eEF2 and the 80S ribosome, including a rearrangement of the functionally important ribosomal intersubunit bridges. Sordarin positions domain III of eEF2 so that it can interact with the sarcin-ricin loop of 25S rRNA and protein rpS23 (S12p). This particular conformation explains the inhibitory action of sordarin and suggests that eEF2 is stalled on the 80S ribosome in a conformation that has similarities with the GTPase activation state. A ratchet-like subunit rearrangement (RSR) occurs in the 80S.eEF2.sordarin complex that, in contrast to Escherichia coli 70S ribosomes, is also present in vacant 80S ribosomes. A model is suggested, according to which the RSR is part of a mechanism for moving the tRNAs during the translocation reaction.
-Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.,Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jorgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J EMBO J. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19. PMID:14976550<ref>PMID:14976550</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 4v4b" style="background-color:#fffaf0;"></div>
 ==See Also==
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 *[[Ribosomal protein S22|Ribosomal protein S22]]
 *[[Ribosome 3D structures|Ribosome 3D structures]]
-== References ==
-<references/>
 __TOC__
 </SX>