1qo2: Difference between revisions

Revision as of 06:30, 3 May 2008

CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE (EC 3.1.3.15, HISA)

OverviewOverview

The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.

About this StructureAbout this Structure

1QO2 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion., Lang D, Thoma R, Henn-Sax M, Sterner R, Wilmanns M, Science. 2000 Sep 1;289(5484):1546-50. PMID:10968789 Page seeded by OCA on Sat May 3 06:30:21 2008

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OCA

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 [[Image:1qo2.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1qo2 |SIZE=350|CAPTION= <scene name='initialview01'>1qo2</scene>, resolution 1.85&Aring;
+The line below this paragraph, containing "STRUCTURE_1qo2", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/D-lyxose_ketol-isomerase D-lyxose ketol-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.15 5.3.1.15] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= THISA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
+-->
-|DOMAIN=
+{{STRUCTURE_1qo2|  PDB=1qo2  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qo2 OCA], [http://www.ebi.ac.uk/pdbsum/1qo2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qo2 RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE (EC 3.1.3.15, HISA)'''
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 [[Category: Thoma, R.]]
 [[Category: Wilmanns, M.]]
-[[Category: histidine biosynthesis]]
+[[Category: Histidine biosynthesis]]
-[[Category: isomerase]]
+[[Category: Isomerase]]
-[[Category: thermophilic protein]]
+[[Category: Thermophilic protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:30:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:35 2008''