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4jgf: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGF FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgf OCA], [https://pdbe.org/4jgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgf RCSB], [https://www.ebi.ac.uk/pdbsum/4jgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgf ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgf OCA], [https://pdbe.org/4jgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgf RCSB], [https://www.ebi.ac.uk/pdbsum/4jgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgf ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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== Function ==
== Function ==
[https://www.uniprot.org/uniprot/CRGD_HUMAN CRGD_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
[https://www.uniprot.org/uniprot/CRGD_HUMAN CRGD_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
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== Publication Abstract from PubMed ==
Up to now, efforts to crystallize the cataract-associated P23T mutant of human gammaD-crystallin have not been successful. Therefore, insights into the light scattering mechanism of this mutant have been exclusively obtained from solution work. Here we present the first crystal structure of the P23T mutant at 2.5 A resolution. The protein exhibits essentially the same overall structure as seen for the wild-type protein. Based on our structural data, we confirm that no major conformational changes are caused by the mutation, and that solution phase properties of the mutant appear exclusively associated with cataract formation. Proteins 2013. (c) 2013 Wiley Periodicals, Inc.
Crystal structure of the cataract-causing P23T gammaD-crystallin mutant.,Ji F, Koharudin LM, Jung J, Gronenborn AM Proteins. 2013 May 13. doi: 10.1002/prot.24321. PMID:23670788<ref>PMID:23670788</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4jgf" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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