4gs3: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GS3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GS3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gs3 OCA], [https://pdbe.org/4gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/4gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gs3 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gs3 OCA], [https://pdbe.org/4gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/4gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gs3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Q8RBI8_CALS4 Q8RBI8_CALS4]  
[https://www.uniprot.org/uniprot/Q8RBI8_CALS4 Q8RBI8_CALS4]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 A by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded beta-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel beta-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.
Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio.,Liebschner D, Brzezinski K, Dauter M, Dauter Z, Nowak M, Kur J, Olszewski M Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1680-9. doi:, 10.1107/S0907444912041637. Epub 2012 Nov 9. PMID:23151633<ref>PMID:23151633</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4gs3" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 14:34, 1 March 2024

Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tencongensis solved ab initioDimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tencongensis solved ab initio

Structural highlights

4gs3 is a 1 chain structure with sequence from Caldanaerobacter subterraneus subsp. tengcongensis MB4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.09Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8RBI8_CALS4

See Also

4gs3, resolution 1.09Å

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