3vdm: Difference between revisions

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<StructureSection load='3vdm' size='340' side='right'caption='[[3vdm]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='3vdm' size='340' side='right'caption='[[3vdm]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptomyces_hygroscopicus_subsp._limoneus"_shibata_et_al._1973 "streptomyces hygroscopicus subsp. limoneus" shibata et al. 1973]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus_subsp._limoneus Streptomyces hygroscopicus subsp. limoneus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDM FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vdn|3vdn]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vldE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264445 "Streptomyces hygroscopicus subsp. limoneus" Shibata et al. 1973])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdm OCA], [https://pdbe.org/3vdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdm RCSB], [https://www.ebi.ac.uk/pdbsum/3vdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdm OCA], [https://pdbe.org/3vdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdm RCSB], [https://www.ebi.ac.uk/pdbsum/3vdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VLDE_STRHL VLDE_STRHL] Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate (PubMed:21766819).<ref>PMID:16725283</ref> <ref>PMID:21766819</ref>
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces hygroscopicus subsp. limoneus shibata et al. 1973]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Asamizu, S]]
[[Category: Streptomyces hygroscopicus subsp. limoneus]]
[[Category: Cavalier, M C]]
[[Category: Asamizu S]]
[[Category: Lee, Y H]]
[[Category: Cavalier MC]]
[[Category: Mahmud, T]]
[[Category: Lee Y-H]]
[[Category: Neau, D]]
[[Category: Mahmud T]]
[[Category: Yim, Y S]]
[[Category: Neau D]]
[[Category: Rossmann fold]]
[[Category: Yim Y-S]]
[[Category: Transferase]]

Latest revision as of 13:35, 1 March 2024

Crystal Structure of VldE, the pseudo-glycosyltransferase which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesisCrystal Structure of VldE, the pseudo-glycosyltransferase which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis

Structural highlights

3vdm is a 2 chain structure with sequence from Streptomyces hygroscopicus subsp. limoneus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.98Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VLDE_STRHL Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate (PubMed:21766819).[1] [2]

See Also

References

  1. ↑ Singh D, Seo MJ, Kwon HJ, Rajkarnikar A, Kim KR, Kim SO, Suh JW. Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704). Gene. 2006 Jul 5;376(1):13-23. doi: 10.1016/j.gene.2005.12.035. Epub 2006 Apr 5. PMID:16725283 doi:http://dx.doi.org/10.1016/j.gene.2005.12.035
  2. ↑ Asamizu S, Yang J, Almabruk KH, Mahmud T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J Am Chem Soc. 2011 Aug 10;133(31):12124-35. doi: 10.1021/ja203574u. Epub 2011, Jul 18. PMID:21766819 doi:http://dx.doi.org/10.1021/ja203574u

3vdm, resolution 1.98Å

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