3ull: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 1: Line 1:


==HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN==
==HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN==
<StructureSection load='3ull' size='340' side='right' caption='[[3ull]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3ull' size='340' side='right'caption='[[3ull]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ull]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ULL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ull]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ULL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ull FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ull OCA], [http://pdbe.org/3ull PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ull RCSB], [http://www.ebi.ac.uk/pdbsum/3ull PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ull ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ull FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ull OCA], [https://pdbe.org/3ull PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ull RCSB], [https://www.ebi.ac.uk/pdbsum/3ull PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ull ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SSBP_HUMAN SSBP_HUMAN]] This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.  
[https://www.uniprot.org/uniprot/SSBP_HUMAN SSBP_HUMAN] This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 18: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ull ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ull ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We solved the crystal structure of the homotetrameric single-stranded DNA binding (SSB) protein from human mitochondria at a resolution of 2.4 A. The tetramer is formed by two dimers interacting head-to-head and shows D2 symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes and eukaryotic mitochondria; this is the first report of an atomic resolution structure of this type of protein. Using biochemical data and analysis of sequence homologies, we were able to correlate the functional properties with structure. We propose that ssDNA wraps around the tetrameric HsmtSSB protein through electropositive channels guided by flexible loops.
Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution.,Yang C, Curth U, Urbanke C, Kang C Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:9033597<ref>PMID:9033597</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ull" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]]
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Curth, U]]
[[Category: Large Structures]]
[[Category: Kang, C]]
[[Category: Curth U]]
[[Category: Urbanke, C]]
[[Category: Kang C]]
[[Category: Yang, C]]
[[Category: Urbanke C]]
[[Category: Dna replication]]
[[Category: Yang C]]
[[Category: Dna-binding protein]]
[[Category: Mitochondrion]]
[[Category: Transit peptide]]

Latest revision as of 13:24, 1 March 2024

HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEINHUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN

Structural highlights

3ull is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SSBP_HUMAN This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ull, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3ull&oldid=4072436"