3ue6: Difference between revisions

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<StructureSection load='3ue6' size='340' side='right'caption='[[3ue6]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='3ue6' size='340' side='right'caption='[[3ue6]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ue6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Conferva_frigida Conferva frigida]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UE6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ue6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaucheria_frigida Vaucheria frigida]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UE6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AUREO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195983 Conferva frigida])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ue6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue6 OCA], [https://pdbe.org/3ue6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ue6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ue6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ue6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ue6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue6 OCA], [https://pdbe.org/3ue6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ue6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ue6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ue6 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A8QW55_VAUFR A8QW55_VAUFR]
Aureochrome1, a signaling photoreceptor from a eukaryotic photosynthetic stramenopile, confers blue-light-regulated DNA binding on the organism. Its topology, in which a C-terminal LOV sensor domain is linked to an N-terminal DNA-binding bZIP effector domain, contrasts with the reverse sensor-effector topology in most other known LOV-photoreceptors. How, then, is signal transmitted in Aureochrome1? The dark- and light-state crystal structures of Aureochrome1 LOV domain (AuLOV) show that its helical N- and C-terminal flanking regions are packed against the external surface of the core beta sheet, opposite to the FMN chromophore on the internal surface. Light-induced conformational changes occur in the quaternary structure of the AuLOV dimer and in Phe298 of the Hbeta strand in the core. The properties of AuLOV extend the applicability of LOV domains as versatile design modules that permit fusion to effector domains via either the N- or C-termini to confer blue-light sensitivity.
 
Crystal structures of Aureochrome1 LOV suggest new design strategies for optogenetics.,Mitra D, Yang X, Moffat K Structure. 2012 Apr 4;20(4):698-706. doi: 10.1016/j.str.2012.02.016. Epub 2012, Apr 3. PMID:22483116<ref>PMID:22483116</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ue6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conferva frigida]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phototropin]]
[[Category: Phototropin]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Mitra, D]]
[[Category: Vaucheria frigida]]
[[Category: Moffat, K]]
[[Category: Mitra D]]
[[Category: Yang, X]]
[[Category: Moffat K]]
[[Category: Fmn-binding blue-light photoreceptor]]
[[Category: Yang X]]
[[Category: Pas/lov domain]]
[[Category: Signaling protein]]

Latest revision as of 13:21, 1 March 2024

The dark structure of the blue-light photoreceptor Aureochrome1 LOVThe dark structure of the blue-light photoreceptor Aureochrome1 LOV

Structural highlights

3ue6 is a 6 chain structure with sequence from Vaucheria frigida. The March 2015 RCSB PDB Molecule of the Month feature on Phototropin by David Goodsell is 10.2210/rcsb_pdb/mom_2015_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A8QW55_VAUFR

3ue6, resolution 2.75Å

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