1qlf: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1qlf.jpg|left|200px]] | [[Image:1qlf.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1qlf", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
| | or leave the SCENE parameter empty for the default display. | ||
| | --> | ||
{{STRUCTURE_1qlf| PDB=1qlf | SCENE= }} | |||
}} | |||
'''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G''' | '''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G''' | ||
| Line 29: | Line 26: | ||
[[Category: Jones, E Y.]] | [[Category: Jones, E Y.]] | ||
[[Category: Tormo, J.]] | [[Category: Tormo, J.]] | ||
[[Category: | [[Category: Antigen]] | ||
[[Category: | [[Category: Glycopeptide]] | ||
[[Category: | [[Category: Histocompatibility]] | ||
[[Category: | [[Category: Immunology]] | ||
[[Category: | [[Category: Mhc]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:24:47 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 06:24, 3 May 2008
MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G
OverviewOverview
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.
About this StructureAbout this Structure
1QLF is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Sendai virus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity., Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T, Immunity. 1999 Jan;10(1):63-74. PMID:10023771 Page seeded by OCA on Sat May 3 06:24:47 2008