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==Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I== | |||
<StructureSection load='8jel' size='340' side='right'caption='[[8jel]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8jel]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JEL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jel OCA], [https://pdbe.org/8jel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jel RCSB], [https://www.ebi.ac.uk/pdbsum/8jel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jel ProSAT]</span></td></tr> | ||
[[Category: Song | </table> | ||
[[Category: Sun | == Function == | ||
[[Category: Zhang | [https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Song J]] | |||
[[Category: Sun J]] | |||
[[Category: Zhang XX]] | |||
Revision as of 12:37, 1 March 2024
Crystal structure of TIGIT in complexed with Ociperlimab, crystal form ICrystal structure of TIGIT in complexed with Ociperlimab, crystal form I
Structural highlights
FunctionTIGIT_HUMAN Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
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