1qh2: Difference between revisions

Revision as of 06:15, 3 May 2008

CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA

OverviewOverview

Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.

About this StructureAbout this Structure

1QH2 is a Protein complex structure of sequences from Nicotiana alata. Full crystallographic information is available from OCA.

ReferenceReference

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein., Lee MC, Scanlon MJ, Craik DJ, Anderson MA, Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353 Page seeded by OCA on Sat May 3 06:15:48 2008

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OCA

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 [[Image:1qh2.jpg|left|200px]]
- {{Structure
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [http://www.ebi.ac.uk/pdbsum/1qh2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB]</span>
-}}
 '''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''
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 [[Category: Lee, M C.S.]]
 [[Category: Scanlon, M J.]]
-[[Category: nicotiana alata]]
+[[Category: Nicotiana alata]]
-[[Category: potato ii trypsin inhibitor]]
+[[Category: Potato ii trypsin inhibitor]]
-[[Category: proteinase inhibitor (chymotrypsin)]]
+[[Category: Serine proteinase inhibitor]]
-[[Category: serine proteinase inhibitor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:15:48 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:28 2008''