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| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/RM02_HUMAN RM02_HUMAN] | | [https://www.uniprot.org/uniprot/RM02_HUMAN RM02_HUMAN] |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Human mitochondrial ribosomes are highly divergent from all other known ribosomes and are specialized to exclusively translate membrane proteins. They are linked with hereditary mitochondrial diseases and are often the unintended targets of various clinically useful antibiotics. Using single-particle electron cryomicroscopy, we have determined the structure of its large subunit to 3.4 angstrom resolution, revealing 48 proteins, 21 of which are specific to mitochondria. The structure unveils an adaptation of the exit tunnel for hydrophobic nascent peptides, extensive remodeling of the central protuberance, including recruitment of mitochondrial tRNAVal to play an integral structural role, and changes in the tRNA binding sites related to the unusual characteristics of mitochondrial tRNAs.
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| Structure of the large ribosomal subunit from human mitochondria.,Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SH, Ramakrishnan V Science. 2014 Oct 2. pii: 1258026. PMID:25278503<ref>PMID:25278503</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 3j7y" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]] | | *[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </SX> | | </SX> |