3fu2: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fu2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FU2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fu2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FU2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fu4|3fu4]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fu2 OCA], [https://pdbe.org/3fu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fu2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fu2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fu2 OCA], [https://pdbe.org/3fu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fu2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fu2 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Riboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis that is selective for the essential nucleobase preQ(1) (7-aminomethyl-7-deazaguanine). The structures reveal a previously unrecognized pseudoknot fold and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional antiterminator.
Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.,Klein DJ, Edwards TE, Ferre-D'Amare AR Nat Struct Mol Biol. 2009 Mar;16(3):343-4. Epub 2009 Feb 22. PMID:19234468<ref>PMID:19234468</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3fu2" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amare, A R.Ferre-D]]
[[Category: Edwards TE]]
[[Category: Edwards, T E]]
[[Category: Ferre-D'Amare AR]]
[[Category: Klein, D J]]
[[Category: Klein DJ]]
[[Category: Aptamer]]
[[Category: Preq1]]
[[Category: Queuosine]]
[[Category: Riboswitch]]
[[Category: Rna]]

Latest revision as of 12:51, 21 February 2024

Cocrystal structure of a class-I preQ1 riboswitchCocrystal structure of a class-I preQ1 riboswitch

Structural highlights

3fu2 is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.85Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

3fu2, resolution 2.85Å

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