3ba8: Difference between revisions
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<StructureSection load='3ba8' size='340' side='right'caption='[[3ba8]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3ba8' size='340' side='right'caption='[[3ba8]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ba8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ba8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BA8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3B8:2-AMINO-7-FLUORO-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE'>3B8</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3B8:2-AMINO-7-FLUORO-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE'>3B8</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba8 OCA], [https://pdbe.org/3ba8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ba8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ba8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ba8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba8 OCA], [https://pdbe.org/3ba8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ba8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ba8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ba8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Enterococcus | [[Category: Enterococcus faecalis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Pinko | [[Category: Pinko C]] | ||
Latest revision as of 12:28, 21 February 2024
Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA LigaseStructural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase
Structural highlights
FunctionDNLJ_ENTFA DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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