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==Crystal structure of the N-terminal domain of UPF0209 protein yfcK from Escherichia coli O157:H7== | ==Crystal structure of the N-terminal domain of UPF0209 protein yfcK from Escherichia coli O157:H7== | ||
<StructureSection load='2qy6' size='340' side='right'caption='[[2qy6]]' scene=''> | <StructureSection load='2qy6' size='340' side='right'caption='[[2qy6]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QY6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2qy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QY6 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy6 OCA], [https://pdbe.org/2qy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qy6 RCSB], [https://www.ebi.ac.uk/pdbsum/2qy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy6 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2qy6 TOPSAN]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy6 OCA], [https://pdbe.org/2qy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qy6 RCSB], [https://www.ebi.ac.uk/pdbsum/2qy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy6 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2qy6 TOPSAN]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MNMC_ECO57 MNMC_ECO57] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.[HAMAP-Rule:MF_01102] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli O157:H7]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Almo SC]] | [[Category: Almo SC]] | ||
Latest revision as of 12:18, 21 February 2024
Crystal structure of the N-terminal domain of UPF0209 protein yfcK from Escherichia coli O157:H7Crystal structure of the N-terminal domain of UPF0209 protein yfcK from Escherichia coli O157:H7
Structural highlights
FunctionMNMC_ECO57 Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.[HAMAP-Rule:MF_01102] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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