1qdn: Difference between revisions

Revision as of 06:09, 3 May 2008

AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)

OverviewOverview

The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure.

About this StructureAbout this Structure

1QDN is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein., May AP, Misura KM, Whiteheart SW, Weis WI, Nat Cell Biol. 1999 Jul;1(3):175-82. PMID:10559905 Page seeded by OCA on Sat May 3 06:09:56 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1qdn.jpg|left|200px]]
- {{Structure
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+{{STRUCTURE_1qdn|  PDB=1qdn  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdn OCA], [http://www.ebi.ac.uk/pdbsum/1qdn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qdn RCSB]</span>
-}}
 '''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''
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 [[Category: Weis, W I.]]
 [[Category: Whiteheart, S W.]]
-[[Category: double-psi beta barrel alpha/beta barrel]]
+[[Category: Double-psi beta barrel alpha/beta barrel]]
-[[Category: vesicular-fusion protein]]
+[[Category: Vesicular-fusion protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:09:56 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:21 2008''