3o63: Difference between revisions

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<StructureSection load='3o63' size='340' side='right'caption='[[3o63]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3o63' size='340' side='right'caption='[[3o63]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o63]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O63 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o63]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O63 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0427, MTCY22G10.11c, Rv0414c, thiE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiamine-phosphate_diphosphorylase Thiamine-phosphate diphosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.3 2.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o63 OCA], [https://pdbe.org/3o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o63 RCSB], [https://www.ebi.ac.uk/pdbsum/3o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o63 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o63 OCA], [https://pdbe.org/3o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o63 RCSB], [https://www.ebi.ac.uk/pdbsum/3o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o63 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/THIE_MYCTU THIE_MYCTU]] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).<ref>PMID:21818324</ref>
[https://www.uniprot.org/uniprot/THIE_MYCTU THIE_MYCTU] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).<ref>PMID:21818324</ref>  


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thiamine-phosphate diphosphorylase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Begley, T P]]
[[Category: Begley TP]]
[[Category: Ealick, S E]]
[[Category: Ealick SE]]
[[Category: Guida, W C]]
[[Category: Guida WC]]
[[Category: Ishida, K]]
[[Category: Ishida K]]
[[Category: McCulloch, K M]]
[[Category: McCulloch KM]]
[[Category: Ramamoorthy, D]]
[[Category: Ramamoorthy D]]
[[Category: Thiamin biosynthesis]]
[[Category: Tim barrel]]
[[Category: Transferase]]

Latest revision as of 13:03, 14 February 2024

Crystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosisCrystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosis

Structural highlights

3o63 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.35Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THIE_MYCTU Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).[1]

See Also

References

  1. ↑ Khare G, Kar R, Tyagi AK. Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs. PLoS One. 2011;6(7):e22441. doi: 10.1371/journal.pone.0022441. Epub 2011 Jul 26. PMID:21818324 doi:http://dx.doi.org/10.1371/journal.pone.0022441

3o63, resolution 2.35Å

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