8g4a: Difference between revisions

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-'''Unreleased structure'''
-The entry 8g4a is ON HOLD  until Paper Publication
+==Human ARNT PAS-B complexed with KG-548 small molecule==
+<StructureSection load='8g4a' size='340' side='right'caption='[[8g4a]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8g4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G4A FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YL8:5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole'>YL8</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g4a OCA], [https://pdbe.org/8g4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g4a RCSB], [https://www.ebi.ac.uk/pdbsum/8g4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g4a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gardner KH]]
+[[Category: Isiorho EA]]
+[[Category: Pimentel Marcelino L]]
+[[Category: Xu X]]