1q59: Difference between revisions
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'''Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2''' | '''Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2''' | ||
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[[Category: Petros, A M.]] | [[Category: Petros, A M.]] | ||
[[Category: Virgin, H W.]] | [[Category: Virgin, H W.]] | ||
[[Category: | [[Category: Bcl-2]] | ||
[[Category: | [[Category: Bhrf1]] | ||
[[Category: | [[Category: Epstein-barr virus]] | ||
[[Category: | [[Category: Nmr spectroscopy]] | ||
[[Category: | [[Category: Structure determination]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:52:44 2008'' | |||
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Revision as of 05:52, 3 May 2008
Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
OverviewOverview
The three-dimensional structure of BHRF1, the Bcl-2 homolog from Epstein-Barr virus (EBV), has been determined by NMR spectroscopy. Although the overall structure is similar to other Bcl-2 family members, there are important structural differences. Unlike some of the other Bcl-2 family members, BHRF1 does not contain the prominent hydrophobic groove that mediates binding to pro-apoptotic family members. In addition, in contrast to the anti-apoptotic Bcl-2 proteins, BHRF1 does not bind tightly to peptides derived from the pro-apoptotic proteins Bak, Bax, Bik, and Bad. The lack of an exposed, pre-formed binding groove in BHRF1 and the lack of significant binding to peptides derived from pro-apoptotic family members that bind to other anti-apoptotic family members, suggest that the mechanism of the BHRF1 anti-apoptotic activity does not parallel that of cellular Bcl-x(L) or Bcl-2.
About this StructureAbout this Structure
1Q59 is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the BHRF1 protein from Epstein-Barr virus, a homolog of human Bcl-2., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, J Mol Biol. 2003 Oct 3;332(5):1123-30. PMID:14499614 Page seeded by OCA on Sat May 3 05:52:44 2008