3jan: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
<SX load='3jan' size='340' side='right' viewer='molstar' caption='[[3jan]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
<SX load='3jan' size='340' side='right' viewer='molstar' caption='[[3jan]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3jan]] is a 88 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAN FirstGlance]. <br>
<table><tr><td colspan='2'>[[3jan]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3jaj|3jaj]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jan OCA], [https://pdbe.org/3jan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jan RCSB], [https://www.ebi.ac.uk/pdbsum/3jan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jan ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jan OCA], [https://pdbe.org/3jan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jan RCSB], [https://www.ebi.ac.uk/pdbsum/3jan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jan ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The universally conserved signal recognition particle (SRP) is essential for the biogenesis of most integral membrane proteins. SRP scans the nascent chains of translating ribosomes, preferentially engaging those with hydrophobic targeting signals, and delivers these ribosome-nascent chain complexes to the membrane. Here, we present structures of native mammalian SRP-ribosome complexes in the scanning and engaged states. These structures reveal the near-identical SRP architecture of these two states, show many of the SRP-ribosome interactions at atomic resolution, and suggest how the polypeptide-binding M domain selectively engages hydrophobic signals. The scanning M domain, pre-positioned at the ribosomal exit tunnel, is auto-inhibited by a C-terminal amphipathic helix occluding its hydrophobic binding groove. Upon engagement, the hydrophobic targeting signal displaces this amphipathic helix, which then acts as a protective lid over the signal. Biochemical experiments suggest how scanning and engagement are coordinated with translation elongation to minimize exposure of hydrophobic signals during membrane targeting.
Structures of the scanning and engaged states of the mammalian SRP-ribosome complex.,Voorhees RM, Hegde RS Elife. 2015 Jul 9;4. doi: 10.7554/eLife.07975. PMID:26158507<ref>PMID:26158507</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3jan" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Signal recognition particle receptor|Signal recognition particle receptor]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Signal recognition particle receptor 3D structures|Signal recognition particle receptor 3D structures]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Hegde, R S]]
[[Category: Hegde RS]]
[[Category: Voorhees, R M]]
[[Category: Voorhees RM]]
[[Category: Mammalian]]
[[Category: Ribosome]]
[[Category: Srp]]
[[Category: Translation]]
[[Category: Translocation]]

Revision as of 11:42, 7 February 2024

Structure of the scanning state of the mammalian SRP-ribosome complexStructure of the scanning state of the mammalian SRP-ribosome complex

3jan, resolution 3.75Å

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3jan&oldid=4047592"