1q2k: Difference between revisions
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{{STRUCTURE_1q2k| PDB=1q2k | SCENE= }} | |||
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'''Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch''' | '''Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch''' | ||
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==About this Structure== | ==About this Structure== | ||
1Q2K is a [[Single protein]] structure | 1Q2K is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2K OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Xu, C.]] | [[Category: Xu, C.]] | ||
[[Category: Xu, Y.]] | [[Category: Xu, Y.]] | ||
[[Category: | [[Category: Alpha-helix]] | ||
[[Category: | [[Category: Beta-sheet]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:47:13 2008'' | |||
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Revision as of 05:47, 3 May 2008
Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch
OverviewOverview
BmBKTx1 is a 31-amino acid peptide identified from the venom of the Chinese scorpion Buthus martensi Karsch, blocking high-conductance calcium-activated potassium channels. Sequence homology analysis indicates that BmBKTx1 is a new subfamily of short-chain alpha-KTx toxins of the potassium channel, which we term alpha-KTx19. Synthetic BmBKTx1 was prepared by using solid-phase peptide synthesis. Two-dimensional NMR spectroscopy techniques were used to determine the solution structure of BmBKTx1. The results show that the BmBKTx1 forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins. The structure of BmBKTx1 consists of a two-stranded antiparallel beta-sheet (residues 20-29) and an alpha-helix (residues 5-15). The three-dimensional structure of BmBKTx1 was also compared with those of two function-related scorpion toxins, charybdotoxin (ChTx) and BmTx1, and their structural and functional implications are discussed.
About this StructureAbout this Structure
1Q2K is a Single protein structure. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch., Cai Z, Xu C, Xu Y, Lu W, Chi CW, Shi Y, Wu J, Biochemistry. 2004 Apr 6;43(13):3764-71. PMID:15049683 Page seeded by OCA on Sat May 3 05:47:13 2008