1bv1: Difference between revisions

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<StructureSection load='1bv1' size='340' side='right'caption='[[1bv1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1bv1' size='340' side='right'caption='[[1bv1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1bv1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betpn Betpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1BV1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1bv1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BV1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BET V 1 1.2801 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3505 BETPN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1bv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bv1 OCA], [http://pdbe.org/1bv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bv1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bv1 OCA], [https://pdbe.org/1bv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bv1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).  
[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN] May be a general steroid carrier protein (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bv1 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bv1 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.
X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.,Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858<ref>PMID:8946858</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1bv1" style="background-color:#fffaf0;"></div>
==See Also==
*[[PYR/PYL/RCAR family of ABA receptors|PYR/PYL/RCAR family of ABA receptors]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Betpn]]
[[Category: Betula pendula]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gajhede, M]]
[[Category: Gajhede M]]
[[Category: Ipsen, H]]
[[Category: Ipsen H]]
[[Category: Joostvan, R J]]
[[Category: Joostvan RJ]]
[[Category: Larson, J N]]
[[Category: Larson JN]]
[[Category: Lowenstein, H]]
[[Category: Lowenstein H]]
[[Category: Osmark, P]]
[[Category: Osmark P]]
[[Category: Poulsen, F M]]
[[Category: Poulsen FM]]
[[Category: Schou, C]]
[[Category: Schou C]]
[[Category: Spangfort, M D]]
[[Category: Spangfort MD]]
[[Category: Allergen]]
[[Category: Pathogenesis-related protein]]

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