1pvh: Difference between revisions

Revision as of 05:31, 3 May 2008

Crystal structure of leukemia inhibitory factor in complex with gp130

OverviewOverview

Gp130 is a shared cell-surface signaling receptor for at least ten different hematopoietic cytokines, but the basis of its degenerate recognition properties is unknown. We have determined the crystal structure of human leukemia inhibitory factor (LIF) bound to the cytokine binding region (CHR) of gp130 at 2.5 A resolution. Strikingly, we find that the shared binding site on gp130 has an entirely rigid core, while the LIF binding interface diverges sharply in structure and chemistry from that of other gp130 ligands. Dissection of the LIF-gp130 interface, along with comparative studies of other gp130 cytokines, reveal that gp130 has evolved a "thermodynamic plasticity" that is relatively insensitive to ligand structure, to enable crossreactivity. These observations reveal a novel and alternative mechanism for degenerate recognition from that of structural plasticity.

About this StructureAbout this Structure

1PVH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130., Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC, Mol Cell. 2003 Sep;12(3):577-89. PMID:14527405 Page seeded by OCA on Sat May 3 05:31:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1pvh.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1pvh |SIZE=350|CAPTION= <scene name='initialview01'>1pvh</scene>, resolution 2.50&Aring;
+The line below this paragraph, containing "STRUCTURE_1pvh", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= IL6ST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LIF OR HILDA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_1pvh|  PDB=1pvh  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pvh OCA], [http://www.ebi.ac.uk/pdbsum/1pvh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pvh RCSB]</span>
-}}
 '''Crystal structure of leukemia inhibitory factor in complex with gp130'''
@@ Line 30: / Line 27: @@
 [[Category: Garcia, K C.]]
 [[Category: Kortemme, T.]]
-[[Category: beta sheet]]
+[[Category: Beta sheet]]
-[[Category: cytokine]]
+[[Category: Cytokine]]
-[[Category: four helix bundle]]
+[[Category: Four helix bundle]]
-[[Category: receptor]]
+[[Category: Receptor]]
-[[Category: signaling]]
+[[Category: Signaling]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:31:55 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:05:07 2008''