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==== | ==Crystal structure of hemoglobin from turkey (Meleagiris gallopova) crystallized in orthorhombic form at 1.4 Angstrom resolution== | ||
<StructureSection load='6zmx' size='340' side='right'caption='[[6zmx]]' scene=''> | <StructureSection load='6zmx' size='340' side='right'caption='[[6zmx]], [[Resolution|resolution]] 1.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[6zmx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMX FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmx OCA], [https://pdbe.org/6zmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmx RCSB], [https://www.ebi.ac.uk/pdbsum/6zmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmx ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.389Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmx OCA], [https://pdbe.org/6zmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmx RCSB], [https://www.ebi.ac.uk/pdbsum/6zmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmx ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HBA_MELGA HBA_MELGA] Involved in oxygen transport from the lung to the various peripheral tissues. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Crystal structures of hemoglobin (Hb) from two flightless birds, ostrich (Struthio camelus) and turkey (Meleagris gallopova), were determined. The ostrich Hb structure was solved to a resolution of 2.22 A, whereas two forms of turkey Hb were solved to resolutions of 1.66 A (turkey monoclinic structure; TMS) and 1.39 A (turkey orthorhombic structure; TOS). Comparison of the amino-acid sequences of ostrich and turkey Hb with those from other avian species revealed no difference in the number of charged residues, but variations were observed in the numbers of hydrophobic and polar residues. Amino-acid-composition-based computation of various physical parameters, in particular their lower inverse transition temperatures and higher average hydrophobicities, indicated that the structures of ostrich and turkey Hb are likely to be highly ordered when compared with other avian Hbs. From the crystal structure analysis, the liganded state of ostrich Hb was confirmed by the presence of an oxygen molecule between the Fe atom and the proximal histidine residue in all four heme regions. In turkey Hb (both TMS and TOS), a water molecule was bound instead of an oxygen molecule in all four heme regions, thus confirming that they assumed the aqua-met form. Analysis of tertiary- and quaternary-structural features led to the conclusion that ostrich oxy Hb and turkey aqua-met Hb adopt the R-/RH-state conformation. | |||
Structural studies of hemoglobin from two flightless birds, ostrich and turkey: insights into their differing oxygen-binding properties.,Ramesh P, Sundaresan SS, Shobana N, Vinuchakkaravarthy T, Sivakumar K, Yasien S, Ponnuswamy MNG Acta Crystallogr D Struct Biol. 2021 May 1;77(Pt 5):690-702. doi:, 10.1107/S2059798321003417. Epub 2021 Apr 26. PMID:33950023<ref>PMID:33950023</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6zmx" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Meleagris gallopavo]] | ||
[[Category: Pandian R]] | |||
[[Category: Ponnuswamy MN]] | |||
[[Category: Sayed Y]] | |||
[[Category: Shobana N]] | |||
[[Category: Sundaresan SS]] | |||