1pu1: Difference between revisions

Revision as of 05:28, 3 May 2008

Solution structure of the Hypothetical protein mth677 from Methanothermobacter Thermautotrophicus

OverviewOverview

The structure of Mth677, a hypothetical protein from Methanobacterium thermoautotrophicum (Mth), has been determined by using heteronuclear nuclear magnetic resonance (NMR) methods on a double-labeled (15)N-(13)C sample. Mth677 adopts a novel alpha+beta fold, consisting of two alpha-helices (one N terminal and one C terminal) packed on the same side of a central beta-hairpin. This structure is likely shared by its three orthologs, detected in three other Archaebacteria. There are no clear features in the sequences of these proteins or in the genome organization of Mth to make a reliable functional assignment to this protein. However, the structural similarity to Escherichia coli MinE, the protein which controls that division occurs at the midcell site, lends support to the proposal that Mth677 might be, in Mth, the counterpart of the topological specificity domain of MinE in E. coli.

About this StructureAbout this Structure

1PU1 is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold., Blanco FJ, Yee A, Campos-Olivas R, Ortiz AR, Devos D, Valencia A, Arrowsmith CH, Rico M, Protein Sci. 2004 Jun;13(6):1458-65. PMID:15152082 Page seeded by OCA on Sat May 3 05:28:56 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1pu1.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1pu1 |SIZE=350|CAPTION= <scene name='initialview01'>1pu1</scene>
+The line below this paragraph, containing "STRUCTURE_1pu1", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= mth677 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus])
+-->
-|DOMAIN=
+{{STRUCTURE_1pu1|  PDB=1pu1  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pu1 OCA], [http://www.ebi.ac.uk/pdbsum/1pu1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pu1 RCSB]</span>
-}}
 '''Solution structure of the Hypothetical protein mth677 from Methanothermobacter Thermautotrophicus'''
@@ Line 32: / Line 29: @@
 [[Category: Valencia, A.]]
 [[Category: Yee, A.]]
-[[Category: alpha and beta protein (a+b)]]
+[[Category: Structural genomic]]
-[[Category: structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:28:56 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:04:32 2008''