8c8b: Difference between revisions

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'''Unreleased structure'''


The entry 8c8b is ON HOLD  until Paper Publication
==Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 48).==
 
<StructureSection load='8c8b' size='340' side='right'caption='[[8c8b]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
Authors: Yosaatmadja, Y., Newman, J.A., Baddock, H.T., Bielinski, M., von Delft, F., Bountra, C., McHugh, P.J., Schofield, C.J., Gileadi, O.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8c8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8B FirstGlance]. <br>
Description: Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 48).
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U1L:4-[[(2~{S})-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-~{N}-prop-2-enyl-quinazoline-2-carboxamide'>U1L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Gileadi, O]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8b OCA], [https://pdbe.org/8c8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8b RCSB], [https://www.ebi.ac.uk/pdbsum/8c8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8b ProSAT]</span></td></tr>
[[Category: Newman, J.A]]
</table>
[[Category: Yosaatmadja, Y]]
== Function ==
[[Category: Bielinski, M]]
[https://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref>
[[Category: Mchugh, P.J]]
== References ==
[[Category: Von Delft, F]]
<references/>
[[Category: Bountra, C]]
__TOC__
[[Category: Schofield, C.J]]
</StructureSection>
[[Category: Baddock, H.T]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baddock HT]]
[[Category: Bielinski M]]
[[Category: Bountra C]]
[[Category: Gileadi O]]
[[Category: McHugh PJ]]
[[Category: Newman JA]]
[[Category: Schofield CJ]]
[[Category: Yosaatmadja Y]]
[[Category: Von Delft F]]

Revision as of 14:40, 1 February 2024

Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 48).Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 48).

Structural highlights

8c8b is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.46Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCR1A_HUMAN May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.[1]

References

  1. ↑ Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol. 2004 Dec;24(23):10448-55. PMID:15542852 doi:http://dx.doi.org/24/23/10448

8c8b, resolution 1.46Å

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