5pyt: Difference between revisions

<table><tr><td colspan='2'>[[5pyt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PYT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pyt OCA], [https://pdbe.org/5pyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pyt RCSB], [https://www.ebi.ac.uk/pdbsum/5pyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pyt ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref>  

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Bradley AR]]

[[Category: Brandao-Neto J]]

[[Category: Brennan PE]]

[[Category: Collins P]]

[[Category: Cox O]]

[[Category: Dias A]]

[[Category: Douangamath A]]

[[Category: Edwards A]]

[[Category: Fairhead M]]

[[Category: Krojer T]]

[[Category: MacLean E]]

[[Category: Ng J]]

[[Category: Pearce NM]]

[[Category: Renjie Z]]

[[Category: Sethi R]]

[[Category: Talon R]]

[[Category: Wright N]]

[[Category: Von Delft F]]