6z4u: Difference between revisions
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==X-ray Crystallographic Structure of Orf9b from SARS-CoV-2== | ==X-ray Crystallographic Structure of Orf9b from SARS-CoV-2== | ||
<StructureSection load='6z4u' size='340' side='right'caption='[[6z4u]]' scene=''> | <StructureSection load='6z4u' size='340' side='right'caption='[[6z4u]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z4U OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6z4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z4U FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z4u OCA], [https://pdbe.org/6z4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z4u RCSB], [https://www.ebi.ac.uk/pdbsum/6z4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z4u ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ORF9B_SARS2 ORF9B_SARS2] Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway.<ref>PMID:32728199</ref> <ref>PMID:34502139</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Severe acute respiratory syndrome coronavirus 2]] | |||
[[Category: De Graef S]] | [[Category: De Graef S]] | ||
[[Category: Munawar A]] | [[Category: Munawar A]] | ||
[[Category: Weeks SD]] | [[Category: Weeks SD]] | ||