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==Structural and Kinetic Evaluation of Phosphoramidate Inhibitors on Thermolysin== | ==Structural and Kinetic Evaluation of Phosphoramidate Inhibitors on Thermolysin== | ||
<StructureSection load='6yi6' size='340' side='right'caption='[[6yi6]]' scene=''> | <StructureSection load='6yi6' size='340' side='right'caption='[[6yi6]], [[Resolution|resolution]] 1.44Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YI6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6yi6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YI6 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yi6 OCA], [https://pdbe.org/6yi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yi6 RCSB], [https://www.ebi.ac.uk/pdbsum/6yi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yi6 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.44Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ORK:(2~{S})-2-[[(2~{S})-4-methyl-2-[[oxidanyl-[(1~{S})-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]amino]pentanoyl]amino]propanoic+acid'>ORK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yi6 OCA], [https://pdbe.org/6yi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yi6 RCSB], [https://www.ebi.ac.uk/pdbsum/6yi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yi6 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/THER_GEOSE THER_GEOSE] Extracellular zinc metalloprotease.<ref>PMID:3149972</ref> | |||
==See Also== | |||
*[[Thermolysin 3D structures|Thermolysin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Geobacillus stearothermophilus]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Heine A]] | [[Category: Heine A]] | ||
[[Category: Klebe G]] | [[Category: Klebe G]] | ||
[[Category: Kljajic M]] | [[Category: Kljajic M]] | ||
Latest revision as of 16:27, 24 January 2024
Structural and Kinetic Evaluation of Phosphoramidate Inhibitors on ThermolysinStructural and Kinetic Evaluation of Phosphoramidate Inhibitors on Thermolysin
Structural highlights
FunctionTHER_GEOSE Extracellular zinc metalloprotease.[1] See AlsoReferences |
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